The Dan Hole River is a 5.1-mile-long (8.2 km) river in the town of Ossipee in eastern New Hampshire in the United States. Its waters flow via the Beech River, Pine River, Ossipee Lake, the Ossipee River, and the Saco River to the Gulf of Maine, an arm of the Atlantic Ocean. The Dan Hole River begins at the outlet of Dan Hole Pond on the southern edge of the Ossipee Mountains.